Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20293076 | 0.73 | LIPE (0.52) | MEN1AHRKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL20293708 | 0.72 | MEN1 (0.43) | MEN1AHRKMT2APDCD1CD274 | |
| SCHEMBL30836800 | 0.72 | MEN1 (0.43) | MEN1AHRKMT2APDCD1CD274 | |
| SCHEMBL30740164 | 0.72 | MEN1 (0.43) | MEN1AHRKMT2APDCD1CD274 | |
| SCHEMBL20293719 | 0.72 | PDCD1 (0.40) | MEN1AHRKMT2APDCD1CD274 | |
| SCHEMBL20293687 | 0.70 | PDCD1 (0.54) | PDCD1CD274 | |
| SCHEMBL29779288 | 0.70 | PDCD1 (0.54) | PDCD1CD274 | |
| SCHEMBL27080495 | 0.68 | PDCD1 (0.42) | MEN1AHRKMT2APDCD1CD274 | |
| SCHEMBL31108230 | 0.67 | PDCD1 (0.60) | PDCD1CD274 | |
| SCHEMBL31108293 | 0.67 | PDCD1 (0.52) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119286-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-06-28 | — | — | WO | disclosed |