Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20322535 | 0.98 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2TSHRSCN1ASCN2A | |
| SCHEMBL22047323 | 0.94 | SCN1A (0.37) | ALDH1A1SMN1; SMN2TSHRSCN1ASCN2A | |
| SCHEMBL26403759 | 0.94 | SCN1A (0.37) | ALDH1A1SMN1; SMN2TSHRSCN1ASCN2A | |
| SCHEMBL18551478 | 0.94 | SCN1A (0.37) | ALDH1A1SMN1; SMN2TSHRSCN1ASCN2A | |
| SCHEMBL20230907 | 0.94 | SCN1A (0.37) | ALDH1A1SMN1; SMN2TSHRSCN1ASCN2A | |
| SCHEMBL20076069 | 0.94 | SCN1A (0.37) | ALDH1A1SMN1; SMN2TSHRSCN1ASCN2A | |
| SCHEMBL20322537 | 0.90 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2TSHRKDM4EPOLB | |
| SCHEMBL20231617 | 0.89 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2TSHRKDM4EPOLB | |
| SCHEMBL23560061 | 0.86 | TSHR (0.41) | ALDH1A1SMN1; SMN2TSHRSCN1ASCN2A | |
| SCHEMBL22802798 | 0.86 | TSHR (0.41) | ALDH1A1SMN1; SMN2TSHRSCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| WO-2018119448-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |