SCHEMBL20324318

SCHEMBL20324318

C#C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(Cl)Oc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 8/20 0.48
ADORA2A P29274 4/20 0.47
PI4KA P42356 1/20 0.47
PI4K2B Q8TCG2 1/20 0.47
PI4K2A Q9BTU6 1/20 0.47
PI4KB Q9UBF8 1/20 0.47
CYP2D6 P10635 9/20 0.45
ALDH1A1 P00352 1/20 0.44
EGFR P00533 1/20 0.43
ADORA1 P30542 1/20 0.42
FGFR1 P11362 1/20 0.41
SLC22A6 Q4U2R8 1/20 0.41
AHCY P23526 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21526818 0.90 CYP3A4 (0.45) CYP3A4ADORA2API4KAPI4K2BPI4K2A
SCHEMBL19370540 0.87 CYP3A4 (0.66) CYP3A4CYP2D6
SCHEMBL14849943 0.87 CYP3A4 (0.66) CYP3A4CYP2D6
SCHEMBL28045212 0.87 CYP3A4 (0.66) CYP3A4CYP2D6
SCHEMBL22182449 0.81 CYP3A4 (0.72) CYP3A4ADORA2ACYP2D6ALDH1A1ADORA1
SCHEMBL23677944 0.79 FGFR1 (0.64) ADORA2API4KAPI4K2BPI4K2API4KB
SCHEMBL21518162 0.77 CYP3A4 (0.64) CYP3A4CYP2D6
SCHEMBL20324856 0.77 CYP3A4 (0.64) CYP3A4CYP2D6
SCHEMBL20324418 0.77 CYP3A4 (0.61) CYP3A4CYP2D6
SCHEMBL28607692 0.77 ADORA2A (0.46) CYP3A4ADORA2API4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019237957-A1 PHOSPHONAMIDE ESTER COMPOUND, SALT THEREOF, RELATED CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2019-12-19 WO disclosed
WO-2018113652-A1 NUCLEOSIDE PHOSPHATE COMPOUND AND PREPARATION METHOD AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2018-06-28 WO disclosed