Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 12/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20326990 | 0.91 | PNP (0.46) | PNPPOLBNT5EHPRT1 | |
| SCHEMBL20324724 | 0.89 | PNP (0.45) | PNPPOLBNT5EHPRT1TGM2 | |
| SCHEMBL20324643 | 0.83 | ALDH1A1 (0.45) | PNP | |
| SCHEMBL20324574 | 0.82 | POLB (0.43) | PNPPOLBNT5ETGM2FUT5 | |
| SCHEMBL20327594 | 0.82 | POLB (0.43) | PNPPOLBNT5ETGM2FUT5 | |
| SCHEMBL20326979 | 0.82 | POLB (0.54) | PNPPOLBNT5EHPRT1TGM2 | |
| SCHEMBL6909710 | 0.82 | POLB (0.54) | PNPPOLBNT5EHPRT1TGM2 | |
| SCHEMBL20324616 | 0.81 | STING1 (0.42) | POLBNT5EFUT5KRAS | |
| SCHEMBL20326916 | 0.79 | STING1 (0.39) | POLBFUT5 | |
| SCHEMBL20324568 | 0.79 | STING1 (0.39) | POLBFUT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |