Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24921953 | 0.98 | EPHX2 (0.40) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL22882634 | 0.98 | EPHX2 (0.40) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL8375368 | 0.98 | EPHX2 (0.40) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL24921954 | 0.95 | EPHX1 (0.42) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL24921957 | 0.95 | EPHX1 (0.37) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL24921943 | 0.95 | EPHX1 (0.42) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL24921930 | 0.95 | EPHX1 (0.42) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL24921944 | 0.95 | EPHX1 (0.42) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL24922152 | 0.95 | EPHX1 (0.42) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 | |
| SCHEMBL24922148 | 0.95 | EPHX1 (0.42) | EPHX2EPHX1L3MBTL4L3MBTL3CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180179183-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179183-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | CRBN, ARAF, VHL | EPHX2 1548/4885EPHX1 2439/4885L3MBTL4 1363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.