Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 14/20 | 0.73 |
| ▸ | CRBN | Q96SW2 | 14/20 | 0.73 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.49 |
| ▸ | GSPT1 | P15170 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20234428 | 0.91 | DDB1 (0.72) | DDB1CRBNSTAT3GPR119GSPT1 | |
| SCHEMBL30805376 | 0.89 | DDB1 (0.70) | DDB1CRBNSTAT3GPR119 | |
| SCHEMBL21069262 | 0.89 | CRBN (0.63) | DDB1CRBNGSPT1 | |
| SCHEMBL24420973 | 0.89 | CRBN (0.71) | DDB1CRBNSTAT3GPR119GSPT1 | |
| SCHEMBL29614567 | 0.89 | CRBN (0.71) | DDB1CRBNSTAT3GPR119GSPT1 | |
| SCHEMBL22848677 | 0.88 | CRBN (0.68) | DDB1CRBNSTAT3GPR119GSPT1 | |
| SCHEMBL20442798 | 0.87 | DDB1 (0.69) | DDB1CRBNSTAT3GPR119GSPT1 | |
| SCHEMBL31294887 | 0.86 | DDB1 (0.68) | DDB1CRBNSTAT3GSPT1 | |
| SCHEMBL28909815 | 0.86 | DDB1 (0.68) | DDB1CRBNSTAT3GPR119GSPT1 | |
| SCHEMBL30805411 | 0.85 | CRBN (0.66) | DDB1CRBNSTAT3GPR119GSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119441-A9 | EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |
| WO-2018119441-A1 | EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |