⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20372771 | 1.00 | — | — | |
| SCHEMBL21077381 | 0.84 | HTR1D (0.30) | — | |
| SCHEMBL18591796 | 0.84 | KDM4E (0.31) | — | |
| SCHEMBL22018414 | 0.84 | KDM4E (0.32) | — | |
| SCHEMBL18591742 | 0.84 | KDM4E (0.31) | — | |
| SCHEMBL23664740 | 0.82 | — | — | |
| SCHEMBL20322536 | 0.81 | SCN1A (0.34) | — | |
| SCHEMBL20443656 | 0.81 | — | — | |
| SCHEMBL19978004 | 0.80 | ALDH1A1 (0.38) | — | |
| SCHEMBL19958965 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10806737-B2 | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides | ARVINAS OPERATIONS, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| WO-2018119441-A1 | EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |