Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.61 |
| ▸ | EGFR | P00533 | 14/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20305537 | 0.92 | EGFR (0.70) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL13498209 | 0.90 | EGFR (0.64) | KDREGFRERBB2 | |
| SCHEMBL641952 | 0.83 | EGFR (0.73) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL25707230 | 0.82 | RET (0.68) | KDREGFRERBB2 | |
| SCHEMBL14066712 | 0.82 | HDAC3 (0.82) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL19220797 | 0.82 | HDAC3 (0.69) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL14066710 | 0.82 | HDAC3 (0.68) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL20305795 | 0.81 | EGFR (0.74) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL19220795 | 0.81 | HDAC3 (0.69) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL643027 | 0.81 | EGFR (0.79) | KDREGFRERBB2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119441-A1 | EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |