Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.43 |
| ▸ | PDE6D | O43924 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 3/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20290478 | 0.89 | STAT3 (0.51) | STAT3CRBNDDB1HDAC3HDAC1 | |
| SCHEMBL24391115 | 0.89 | CRBN (0.45) | STAT3CRBNDDB1HDAC8HDAC3 | |
| SCHEMBL14601086 | 0.85 | CRBN (0.46) | STAT3CRBNDDB1CA2HDAC3 | |
| SCHEMBL24938223 | 0.85 | CRBN (0.51) | STAT3CRBNDDB1CA2HDAC3 | |
| SCHEMBL25102496 | 0.84 | HDAC1 (0.47) | STAT3CRBNDDB1CA2HDAC3 | |
| SCHEMBL20291132 | 0.83 | CRBN (0.66) | STAT3CRBNDDB1HDAC8CA2 | |
| SCHEMBL24142296 | 0.82 | CRBN (0.46) | STAT3CRBNDDB1CA2HDAC3 | |
| SCHEMBL24391195 | 0.82 | CRBN (0.67) | STAT3CRBNDDB1HDAC8CA2 | |
| SCHEMBL21303955 | 0.82 | STAT3 (0.49) | STAT3CRBNDDB1CA2 | |
| SCHEMBL18492637 | 0.82 | CRBN (0.51) | STAT3CRBNDDB1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180179522-A1 | TUNABLE ENDOGENOUS PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179522-A1 | TUNABLE ENDOGENOUS PROTEIN DEGRADATION | PSMG3, MYCBP, DBN1 | STAT3 2603/4885CRBN 138/4885DDB1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.