Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 6/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251949 | 0.95 | FGFR4 (0.35) | FGFR4FGFR1FGFR2PTPN11PIK3CA | |
| SCHEMBL20332008 | 0.93 | FGFR4 (0.35) | FGFR4FGFR1FGFR2 | |
| SCHEMBL21251782 | 0.89 | PIK3CA (0.36) | FGFR4FGFR1FGFR2PTPN11PIK3CA | |
| SCHEMBL21252292 | 0.89 | MAP3K12 (0.36) | FGFR4FGFR1FGFR2 | |
| SCHEMBL21252482 | 0.87 | FGFR4 (0.37) | FGFR4FGFR1FGFR2PIK3CAMTOR | |
| SCHEMBL21252119 | 0.86 | PDE9A (0.36) | FGFR4FGFR1FGFR2 | |
| SCHEMBL20332031 | 0.85 | PDE9A (0.38) | FGFR4FGFR1FGFR2 | |
| SCHEMBL20331978 | 0.85 | PDE9A (0.39) | FGFR4FGFR1FGFR2 | |
| SCHEMBL21252283 | 0.85 | MAP3K12 (0.32) | PIK3CAMTOR | |
| SCHEMBL21240075 | 0.85 | PDE9A (0.38) | FGFR4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |