Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
| ▸ | GAK | O14976 | 1/20 | 0.30 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252007 | 0.94 | PIK3CA (0.36) | PIK3CAMTORTRPC6MAP4K1GAK | |
| SCHEMBL21252476 | 0.92 | MAP3K12 (0.34) | MAP3K12PIK3CAMTORMAP4K1 | |
| SCHEMBL20332234 | 0.90 | PDE9A (0.36) | MAP4K1 | |
| SCHEMBL21240252 | 0.89 | PDE9A (0.37) | MAP4K1 | |
| SCHEMBL21251949 | 0.89 | FGFR4 (0.35) | PIK3CAMTOR | |
| SCHEMBL20332029 | 0.85 | FGFR4 (0.34) | PIK3CAMTOR | |
| SCHEMBL21252282 | 0.85 | JAK2 (0.34) | MAP3K12GAK | |
| SCHEMBL21252150 | 0.84 | MAP3K12 (0.33) | MAP3K12PIK3CAMTORTRPC6MAP4K1 | |
| SCHEMBL21240428 | 0.83 | PDE9A (0.40) | MAP4K1PRKCA | |
| SCHEMBL21251782 | 0.83 | PIK3CA (0.36) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |