Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602307 | 0.93 | OGA (0.46) | NR1H2MAPTKDM4EHDAC1HDAC6 | |
| SCHEMBL21816667 | 0.90 | NR1H2 (0.46) | NR1H2MAPTKDM4EHDAC1HDAC6 | |
| SCHEMBL20333548 | 0.88 | KMT2A (0.46) | NR1H2MAPTKDM4EHDAC1HDAC6 | |
| SCHEMBL20304927 | 0.88 | KMT2A (0.46) | NR1H2MAPTKDM4EHDAC1HDAC6 | |
| SCHEMBL20304926 | 0.88 | KMT2A (0.46) | NR1H2MAPTKDM4EHDAC1HDAC6 | |
| SCHEMBL20304748 | 0.88 | SRD5A2 (0.50) | NR1H2MAPTKDM4EESR2HDAC1 | |
| SCHEMBL20304747 | 0.88 | SRD5A2 (0.50) | NR1H2MAPTKDM4EESR2HDAC1 | |
| SCHEMBL23906274 | 0.84 | ESR2 (0.47) | NR1H2MAPTKDM4EESR2HDAC1 | |
| SCHEMBL25699835 | 0.84 | NR1H2 (0.58) | NR1H2MAPTKDM4EESR2HDAC1 | |
| SCHEMBL20305039 | 0.84 | ALDH1A1 (0.46) | MAPTOGAPIM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573497-A | Histone deacetylase inhibitors | 生物马林药物股份有限公司 | 2019-12-13 | — | — | CN | disclosed |
| WO-2018119362-A2 | HISTONE DEACETYLASE INHIBITORS | BIOMARIN PHARMACEUTICALS INC. (US) | 2018-06-28 | — | — | WO | disclosed |