Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15044413 | 0.92 | TSHR (0.58) | TSHREPHX2LMNAALDH1A1 | |
| SCHEMBL381238 | 0.85 | EPHX2 (0.50) | TSHREPHX2LMNAALDH1A1RECQL | |
| SCHEMBL4103229 | 0.85 | EPHX2 (0.50) | TSHREPHX2LMNAALDH1A1RECQL | |
| SCHEMBL9307831 | 0.84 | PRMT1 (0.41) | EPHX2LMNAALDH1A1ADRA1AEPHX1 | |
| SCHEMBL9308061 | 0.84 | PRMT1 (0.41) | EPHX2LMNAALDH1A1ADRA1AEPHX1 | |
| SCHEMBL11792895 | 0.83 | EPHX2 (0.54) | TSHREPHX2ALDH1A1 | |
| SCHEMBL5840681 | 0.83 | EPHX2 (0.54) | TSHREPHX2ALDH1A1 | |
| SCHEMBL10057015 | 0.83 | TSHR (0.55) | TSHREPHX2LMNAALDH1A1RECQL | |
| SCHEMBL4093088 | 0.82 | TSHR (0.52) | TSHREPHX2LMNAALDH1A1RECQL | |
| SCHEMBL6014001 | 0.82 | EPHX1 (0.64) | TSHREPHX2LMNAALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754094-B2 | Methods for heat shock protein dependent cancer treatment | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2014-06-17 | — | — | US | disclosed |
| US-20110160160-A1 | METHODS FOR HEAT SHOCK PROTEIN DEPENDENT CANCER TREATMENT | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2011-06-30 | — | — | US | disclosed |
| WO-2009023846-A2 | METHODS FOR HEAT SHOCK PROTEIN DEPENDENT CANCER TREATMENT | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2009-02-19 | — | — | WO | disclosed |