Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22216489 | 0.90 | MAPT (0.57) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL2060705 | 0.81 | NR1H4 (0.73) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL20350478 | 0.81 | MAPT (0.55) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL4428019 | 0.80 | MAPT (0.71) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL28133927 | 0.80 | MAPT (0.70) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL2362772 | 0.80 | KMT2A (0.82) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL4347151 | 0.79 | MAPT (0.64) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL14062901 | 0.78 | MAPT (0.67) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL678394 | 0.77 | MAPT (0.69) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL20333384 | 0.77 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2KMT2ARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119284-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2018-06-28 | — | — | WO | disclosed |