Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20347415 | 0.85 | PTPN1 (0.46) | SMN1; SMN2PTPN1TSHRHTTL3MBTL1 | |
| SCHEMBL20350802 | 0.84 | PTPN1 (0.44) | SMN1; SMN2PTPN1TSHRHTTL3MBTL1 | |
| SCHEMBL934104 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2PTPN1TSHRLMNACYP1A2 | |
| SCHEMBL20333383 | 0.77 | MAPT (0.60) | SMN1; SMN2TSHRKMT2AMEN1LMNA | |
| SCHEMBL20333381 | 0.77 | RXRA (0.39) | SMN1; SMN2PTPN1LMNAALDH1A1CYP3A4 | |
| SCHEMBL20350718 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2TSHRL3MBTL1KMT2AMEN1 | |
| SCHEMBL11989506 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2PTPN1TSHRHTTL3MBTL1 | |
| SCHEMBL15577125 | 0.74 | BLM (0.40) | SMN1; SMN2PTPN1TSHRHSD17B10KMT2A | |
| SCHEMBL15577140 | 0.74 | BLM (0.40) | SMN1; SMN2PTPN1TSHRHSD17B10KMT2A | |
| SCHEMBL20333769 | 0.74 | FFAR1 (0.50) | L3MBTL1LMNACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119284-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2018-06-28 | — | — | WO | disclosed |