Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891347 | 0.92 | LTA4H (0.78) | LTA4HKCNH2 | |
| SCHEMBL1886153 | 0.85 | LTA4H (0.77) | LTA4HKCNH2 | |
| SCHEMBL1891796 | 0.83 | LTA4H (0.76) | LTA4HKCNH2 | |
| SCHEMBL2169624 | 0.80 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL1886913 | 0.79 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL2167591 | 0.78 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL1008015 | 0.76 | LTA4H (0.79) | LTA4HKCNH2 | |
| SCHEMBL2032184 | 0.75 | LTA4H (0.70) | LTA4HKCNH2 | |
| SCHEMBL1895734 | 0.74 | LTA4H (0.72) | LTA4HKCNH2 | |
| SCHEMBL1888687 | 0.73 | LTA4H (0.62) | LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336125-A1 | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | Janssen Pharmaceutica N.V. (BE) | 2011-06-22 | — | — | EP | disclosed |