Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21794806 | 0.85 | — | — | |
| SCHEMBL25411860 | 0.80 | ATM (0.37) | ATMAGTR2ACE | |
| SCHEMBL27128389 | 0.80 | ATM (0.37) | ATMAGTR2ACE | |
| SCHEMBL27284170 | 0.79 | AGTR2 (0.36) | AGTR2ACE | |
| SCHEMBL20314977 | 0.79 | CACNA1A (0.36) | AGTR2ACESRC | |
| SCHEMBL21610061 | 0.79 | JAK3 (0.36) | JAK3SRC | |
| SCHEMBL20161664 | 0.79 | JAK3 (0.36) | JAK3SRC | |
| SCHEMBL24476768 | 0.79 | JAK3 (0.36) | JAK3SRC | |
| SCHEMBL14849286 | 0.78 | ATM (0.48) | ATMAGTR2ACEKMT2A | |
| SCHEMBL22128407 | 0.76 | SRC (0.36) | ACESRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |
| WO-2018119183-A2 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | AMGEN INC. (US) | 2018-06-28 | — | — | WO | disclosed |