Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.52 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485340 | 0.89 | MAPT (0.68) | MAPTALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL29937559 | 0.89 | MAPT (0.68) | MAPTALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL23850863 | 0.86 | ALDH1A1 (0.62) | MAPTALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL31587805 | 0.86 | ALDH1A1 (0.62) | MAPTALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL31588237 | 0.84 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL23850714 | 0.84 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL31053843 | 0.83 | MAPT (0.64) | MAPTALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL25025040 | 0.83 | MAPT (0.64) | MAPTALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL18587113 | 0.83 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL28744772 | 0.83 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10239869-B2 | Sulfonamide compounds as voltage-gated sodium channel modulators | LUPIN LIMITED (IN) | 2019-03-26 | — | — | US | disclosed |
| CN-108349957-A | Sulfonamide compounds as modulators of voltage-gated sodium channels | 鲁平有限公司 | 2018-07-31 | — | — | CN | disclosed |
| US-20180186777-A1 | SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS | LUPIN LIMITED (IN) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10239869-B2 | Sulfonamide compounds as voltage-gated sodium channel modulators | SCN7A, SCN1A, SCN5A | MAPT 3029/4885ALDH1A1 1647/4885SMN1; SMN2 427/4885 |
| US-20180186777-A1 | SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS | SCN7A, SCN1A, SCN5A | MAPT 3029/4885ALDH1A1 1647/4885SMN1; SMN2 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.