Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 7/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycinebetaine SCHEMBL8678519 | 0.94 | TSHR (0.53) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Betaine SCHEMBL31467313 | 0.94 | — | — | |
| Glycinebetaine SCHEMBL2803780 | 0.94 | TSHR (0.53) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Glycinebetaine SCHEMBL4900209 | 0.94 | — | — | |
| Glycinebetaine SCHEMBL7739 | 0.94 | — | — | |
| Glycinebetaine SCHEMBL9785894 | 0.92 | TSHR (0.46) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Glycinebetaine SCHEMBL18957544 | 0.92 | FFAR3 (0.46) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Glycinebetaine SCHEMBL8725957 | 0.91 | — | — | |
| Glycinebetaine SCHEMBL11109389 | 0.91 | — | — | |
| Glycinebetaine SCHEMBL4457941 | 0.91 | TSHR (0.50) | TSHRALDH1A1LMNAAPEX1SLC22A16 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113930813-B | Electro-coppering solution applied to wafer-level packaging and electroplating process thereof | 珠海市创智芯科技有限公司 | 2022-04-08 | — | — | CN | claimed |
| CN-113930813-A | Electro-coppering solution applied to wafer-level packaging and electroplating process thereof | 珠海市创智芯科技有限公司 | 2022-01-14 | — | — | CN | claimed |
| WO-2024040253-A1 | EPIGENETIC MODULATION OF GENOMIC TARGETS TO CONTROL EXPRESSION OF PWS-ASSOCIATED GENES | DUKE UNIVERSITY (US) | 2024-02-22 | — | — | WO | disclosed |
| EP-4314302-A1 | TETRACYCLINE-INDUCIBLE EXPRESSION SYSTEMS | DNA TWOPOINTO INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| US-20230323396-A1 | TETRACYCLINE-INDUCIBLE EXPRESSION SYSTEM | DNA TWOPOINTO INC. (US) | 2023-10-12 | — | — | US | disclosed |
| CN-116583599-A | Reprogrammable IscB nucleases and uses thereof | 博德研究所 | 2023-08-11 | — | — | CN | disclosed |
| CN-116234918-A | I-type CRISPR related transposase system | 博德研究所 | 2023-06-06 | — | — | CN | disclosed |
| US-11566262-B2 | Tetracycline-inducible expression systems | DNA TWOPOINTO INC. (US) | 2023-01-31 | — | — | US | disclosed |
| CN-115461118-A | Compositions and methods for treating familial hypercholesterolemia and increased low density lipoprotein cholesterol | 萨利欧基因治疗公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-115461082-A | Compositions and methods for treating hereditary macular degeneration | 萨利欧基因治疗公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-115175996-A | Novel type VI CRISPR enzymes and systems | 博德研究所 | 2022-10-11 | — | — | CN | disclosed |
| CN-115175991-A | Engineered muscle targeting compositions | 博德研究所 | 2022-10-11 | — | — | CN | disclosed |
| CN-114981423-A | I-B type CRISPR-associated transposase system | 博德研究所 | 2022-08-30 | — | — | CN | disclosed |
| EP-4038204-A1 | EPIGENETIC MODULATION OF GENOMIC TARGETS TO CONTROL EXPRESSION OF PWS-ASSOCIATED GENES | Duke University (US) | 2022-08-10 | — | — | EP | disclosed |
| CN-113930813-B | Electro-coppering solution applied to wafer-level packaging and electroplating process thereof | 珠海市创智芯科技有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-113930813-A | Electro-coppering solution applied to wafer-level packaging and electroplating process thereof | 珠海市创智芯科技有限公司 | 2022-01-14 | — | — | CN | disclosed |
| WO-2021067878-A1 | EPIGENETIC MODULATION OF GENOMIC TARGETS TO CONTROL EXPRESSION OF PWS-ASSOCIATED GENES | DUKE UNIVERSITY (US) | 2021-04-08 | — | — | WO | disclosed |
| US-10620214-B2 | Chloroalkane penetration method for quantifying access of a molecule into a cell | TRUSTEES OF TUFTS COLLEGE (US) | 2020-04-14 | — | — | US | disclosed |
| US-20180188260-A1 | METHOD OF QUANTIFYING CELL PENETRATION OF A MOLECULE | TRUSTEES OF TUFTS COLLEGE (US) | 2018-07-05 | — | — | US | disclosed |