Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 4/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2033741 | 1.00 | PRKCZ (0.41) | PRKCZHRH2HRH1HSP90AB1EIF4E | |
| SCHEMBL12541138 | 0.88 | EIF4E (0.38) | PRKCZHRH2HRH1HSP90AB1EIF4E | |
| SCHEMBL12541140 | 0.88 | EIF4E (0.38) | PRKCZHRH2HRH1HSP90AB1EIF4E | |
| SCHEMBL2032280 | 0.81 | EGLN2 (0.37) | PRKCZHRH2HRH1HSP90AB1EIF4E | |
| SCHEMBL2033179 | 0.79 | PRKCZ (0.43) | PRKCZHRH2HRH1HSP90AB1EIF4E | |
| SCHEMBL2034932 | 0.78 | MAPK14 (0.38) | HRH2HRH1EIF4EALDH1A1MAPT | |
| SCHEMBL2034990 | 0.71 | CYP1A1 (0.41) | HRH2HRH1EIF4EMAPT | |
| SCHEMBL2050458 | 0.71 | EIF4E (0.35) | HRH2HRH1EIF4EALDH1A1GAA | |
| SCHEMBL2050457 | 0.71 | EIF4E (0.35) | HRH2HRH1EIF4EALDH1A1GAA | |
| SCHEMBL13262820 | 0.70 | ESR1 (0.54) | MAOBTTRDPP4EPAS1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512247-A1 | NOVEL THIOPHENE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE | N30 Pharmaceuticals, LLC (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075478-A1 | NOVEL THIOPHENE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE | N30 PHARMACEUTICALS, LLC (US) | 2011-06-23 | — | — | WO | disclosed |