Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 3/20 | 0.68 |
| ▸ | STAMBP | O95630 | 1/20 | 0.68 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 6/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | COMT | P21964 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30643089 | 1.00 | PSMD14 (0.68) | PSMD14STAMBPCOPS5KDM4EPIM1 | |
| SCHEMBL2204711 | 0.85 | PSMD14 (0.67) | PSMD14STAMBPCOPS5KDM4EPAX8 | |
| SCHEMBL6986553 | 0.83 | PSMD14 (0.68) | PSMD14STAMBPCOPS5PARP1 | |
| Hydrochloric Acid SCHEMBL16027160 | 0.83 | PSMD14 (0.65) | PSMD14STAMBPCOPS5KDM4EPAX8 | |
| SCHEMBL30537997 | 0.82 | PSMD14 (0.66) | PSMD14STAMBPCOPS5KDM4EPARP1 | |
| SCHEMBL19346770 | 0.82 | PSMD14 (0.66) | PSMD14STAMBPCOPS5PARP1 | |
| SCHEMBL13977542 | 0.82 | PSMD14 (0.66) | PSMD14STAMBPCOPS5PARP1 | |
| SCHEMBL17629674 | 0.82 | PSMD14 (0.66) | PSMD14STAMBPCOPS5KDM4EPARP1 | |
| SCHEMBL29688144 | 0.82 | PSMD14 (0.66) | PSMD14STAMBPCOPS5PARP1 | |
| SCHEMBL18526855 | 0.81 | PSMD14 (1.00) | PSMD14STAMBPCOPS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509954-A1 | 4 -OXO- 1H -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2012-10-17 | — | — | EP | claimed |
| WO-2011072241-A1 | 4 -OXO- IH -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-16 | — | — | WO | claimed |
| EP-2509954-A1 | 4 -OXO- 1H -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072241-A1 | 4 -OXO- IH -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-16 | — | — | WO | disclosed |