Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | CASP3 | P42574 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30229677 | 1.00 | MDM4 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL20299891 | 1.00 | MDM4 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL5260936 | 1.00 | MDM4 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL29989746 | 0.91 | CASP3 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL30082405 | 0.91 | CASP3 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL29401317 | 0.91 | CASP3 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL13946516 | 0.91 | CASP3 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL14940666 | 0.91 | CASP3 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL1253102 | 0.91 | CASP3 (0.54) | MDM4TP53CASP3KMT2AEPHX2 | |
| SCHEMBL29989676 | 0.91 | CASP3 (0.54) | MDM4TP53CASP3KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618054-B2 | Interleukin-1 receptor antagonists, compositions, and methods of treatment | Valorisation-Rechereche Société en Commandite (CA) | 2013-12-31 | — | — | US | disclosed |
| EP-2366786-A2 | Cytokine receptor modulators and uses thereof | VALORISATION HSJ, Société en Commandite (CA) | 2011-09-21 | — | — | EP | disclosed |
| US-20110144014-A1 | CYTOKINE RECEPTOR MODULATORS AND USES THEREOF | CENTRE HOSPITALIER UNIVERSITAIRE SAINTE-JUSTINE (CA) | 2011-06-16 | — | — | US | disclosed |
| US-20100041609-A1 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT | VALORISATION-RECHERCHE, SOCIETE EN COMMANDITE (CA) | 2010-02-18 | — | — | US | disclosed |
| US-20090048161-A1 | Cytokine receptor modulators and uses thereof | VALORISATION HSJ, SOCIETE EN COMMANDITE (CA) | 2009-02-19 | — | — | US | disclosed |
| US-20060094663-A1 | Interleukin-1 receptor antagonists, compositions, and methods of treatment | VALORISATION-RECHERCHE, SOCIETE EN COMMANDITE (CA) | 2006-05-04 | — | — | US | disclosed |