SCHEMBL20338702

SCHEMBL20338702

O=C(O)c1ccc(Nc2nccc3ccc(Cl)cc23)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNF P01375 1/20 0.51
MAPKAPK2 P49137 1/20 0.51
CSNK2A1 P68400 4/20 0.49
CSNK2A2 P19784 3/20 0.49
CSNK2B P67870 2/20 0.49
POLB P06746 2/20 0.49
DHODH Q02127 2/20 0.49
MEN1 O00255 1/20 0.49
RAB9A P51151 1/20 0.49
KMT2A Q03164 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
HDAC3 O15379 2/20 0.47
HDAC1 Q13547 2/20 0.47
HDAC6 Q9UBN7 2/20 0.47
AURKA O14965 4/20 0.47
BRAF P15056 1/20 0.46
KDR P35968 1/20 0.46
CAMK2D Q13557 1/20 0.46
PHLPP2 Q6ZVD8 1/20 0.45
RXRA P19793 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29786964 0.87 CSNK2A1 (0.55) TNFMAPKAPK2CSNK2A1CSNK2A2CSNK2B
SCHEMBL20338809 0.87 CSNK2A1 (0.55) TNFMAPKAPK2CSNK2A1CSNK2A2CSNK2B
SCHEMBL29787033 0.86 TNF (0.57) TNFPOLBDHODHMEN1RAB9A
SCHEMBL20338691 0.86 TNF (0.57) TNFPOLBDHODHMEN1RAB9A
SCHEMBL29786941 0.84 P4HTM (0.48) TNFCSNK2A1CSNK2A2CSNK2BDHODH
SCHEMBL20356763 0.84 P4HTM (0.48) TNFCSNK2A1CSNK2A2CSNK2BDHODH
SCHEMBL29786991 0.84 HCAR3 (0.47) CSNK2A1CSNK2A2CSNK2B
SCHEMBL20338847 0.84 HCAR3 (0.47) CSNK2A1CSNK2A2CSNK2B
SCHEMBL29787022 0.83 TNF (0.44) TNFCSNK2A1CSNK2A2CSNK2BDHODH
SCHEMBL20338676 0.83 TNF (0.44) TNFCSNK2A1CSNK2A2CSNK2BDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11440898-B2 Isoquinoline compounds, methods for their preparation, and therapeutic uses thereof in conditions associated with the alteration of the activity of beta galactosidase MINORYX THERAPEUTICS S.L. (ES) 2022-09-13 US disclosed
CN-110494432-B Isoquinoline compounds, methods of preparation thereof and therapeutic use thereof in disorders associated with altered beta-galactosidase activity 米尼奥尔克斯治疗有限公司 2022-08-12 CN disclosed
EP-3562821-B9 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE MINORYX THERAPEUTICS S L (ES) 2021-05-26 EP disclosed
EP-3562821-B9 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE MINORYX THERAPEUTICS S L (ES) 2021-05-26 EP disclosed
EP-3562821-B1 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE MINORYX THERAPEUTICS S L (ES) 2020-12-02 EP disclosed
EP-3562821-B1 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE MINORYX THERAPEUTICS S L (ES) 2020-12-02 EP disclosed
US-20200071294-A1 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE MINORYX THERAPEUTICS S.L. (ES) 2020-03-05 US disclosed
US-20200071294-A1 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE MINORYX THERAPEUTICS S.L. (ES) 2020-03-05 US disclosed
EP-3562821-A1 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE Minoryx Therapeutics S.L. (ES) 2019-11-06 EP disclosed
WO-2018122746-A1 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE MINORYX THERAPEUTICS S.L. (ES) 2018-07-05 WO disclosed
WO-2018122746-A1 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE MINORYX THERAPEUTICS S.L. (ES) 2018-07-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11440898-B2 Isoquinoline compounds, methods for their preparation, and therapeutic uses thereof in conditions associated with the alteration of the activity of beta galactosidase GLB1, GBA1, GALC TNF 2513/4885MAPKAPK2 4363/4885CSNK2A1 701/4885
US-20200071294-A1 ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE GLB1, GBA1, GALC TNF 2513/4885MAPKAPK2 4363/4885CSNK2A1 701/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.