Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19612311 | 1.00 | CYP3A4 (0.51) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL3782141 | 0.92 | CYP1A2 (0.57) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL20339408 | 0.88 | LMNA (0.49) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL9697377 | 0.88 | LMNA (0.49) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL3787607 | 0.85 | MCHR1 (0.47) | CYP3A4MEN1LMNACHRM2MAPT | |
| SCHEMBL2859001 | 0.83 | LMNA (0.62) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL9387360 | 0.83 | LMNA (0.62) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL1964196 | 0.83 | LMNA (0.62) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL2245919 | 0.83 | LMNA (0.62) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL9394792 | 0.83 | LMNA (0.62) | CYP3A4MEN1NR1I2LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562488-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCY WITH SMALL MOLECULE NF-KB INHIBITORS | Memorial Sloan-Kettering Cancer Center (US) | 2019-11-06 | — | — | EP | disclosed |
| US-20190314377-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCY WITH SMALL MOLECULE NF-KB INHIBITORS | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2019-10-17 | — | — | US | disclosed |
| WO-2018125867-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCY WITH SMALL MOLECULE NF-KB INHIBITORS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2018-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190314377-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCY WITH SMALL MOLECULE NF-KB INHIBITORS | NFKBIA, IKBKB, NFKB2 | CYP3A4 4411/4885MEN1 845/4885NR1I2 1934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.