Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | CPT2 | P23786 | 1/20 | 0.50 |
| ▸ | CPT1A | P50416 | 1/20 | 0.50 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15286922 | 0.94 | PROKR1 (0.51) | KDM4EHPGDPARP1CPT2CPT1A | |
| SCHEMBL15450884 | 0.88 | KDM4E (0.51) | KDM4EHPGDPARP1CPT2CPT1A | |
| SCHEMBL18949715 | 0.85 | GRIN2D (0.60) | KDM4EHPGDALDH1A1HSD17B10HTT | |
| SCHEMBL15228566 | 0.84 | PIK3CA (0.48) | KDM4EHPGDALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL19998582 | 0.82 | USP30 (0.52) | KDM4EHPGDCPT2CPT1ACPT1B | |
| SCHEMBL30525303 | 0.81 | OPRD1 (0.55) | KDM4EHPGDALDH1A1HSD17B10GRIN2D | |
| SCHEMBL28772301 | 0.81 | GRM5 (0.60) | KDM4EHPGDALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL322198 | 0.81 | KMT2A (0.48) | KDM4EHPGDALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL390627 | 0.81 | HRH3 (0.57) | KDM4EHPGDALDH1A1HSD17B10HTT | |
| SCHEMBL16795243 | 0.81 | GRIN2D (0.51) | KDM4EHPGDALDH1A1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562822-A1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | Mitobridge, Inc. (US) | 2019-11-06 | — | — | EP | disclosed |
| WO-2018125961-A1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| CN-102803225-A | Imidazole derivatives and their use as modulators of cyclin dependent kinases | NOVARTIS AG | 2012-11-28 | — | — | CN | disclosed |