Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 known ✓ | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 known ✓ | P32297 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DGKA | P23743 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL22394365 | 1.00 | ALDH1A1 (0.68) | ALDH1A1TSHRCYP3A4CES2RARB | |
| Acetic Acid SCHEMBL2150763 | 1.00 | ALDH1A1 (0.68) | ALDH1A1TSHRCYP3A4CES2RARB | |
| Acetic Acid Butyl Ester SCHEMBL6829205 | 0.98 | ALDH1A1 (0.72) | ALDH1A1TSHRCYP3A4CES2RARB | |
| SCHEMBL22372 | 0.96 | ALDH1A1 (0.74) | ALDH1A1TSHRCYP3A4CES2RARB | |
| SCHEMBL8125550 | 0.96 | ALDH1A1 (0.74) | ALDH1A1TSHRCYP3A4CES2RARB | |
| SCHEMBL275015 | 0.96 | ALDH1A1 (0.74) | ALDH1A1TSHRCYP3A4CES2RARB | |
| SCHEMBL48354 | 0.96 | ALDH1A1 (0.74) | ALDH1A1TSHRCYP3A4CES2RARB | |
| SCHEMBL2702326 | 0.96 | ALDH1A1 (0.74) | ALDH1A1TSHRCYP3A4CES2RARB | |
| SCHEMBL13523596 | 0.96 | ALDH1A1 (0.74) | ALDH1A1TSHRCYP3A4CES2RARB | |
| SCHEMBL1924009 | 0.94 | ALDH1A1 (0.71) | ALDH1A1TSHRCYP3A4CES2RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11678661-B2 | Thickened organic liquid compositions with polymeric rheology modifiers | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2023-06-20 | — | — | US | disclosed |
| EP-3565409-A1 | THICKENED ORGANIC LIQUID COMPOSITIONS WITH POLYMERIC RHEOLOGY MODIFIERS | Nouryon Chemicals International B.V. (NL) | 2019-11-13 | — | — | EP | disclosed |
| WO-2018122122-A1 | THICKENED ORGANIC LIQUID COMPOSITIONS WITH POLYMERIC RHEOLOGY MODIFIERS | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2018-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11678661-B2 | Thickened organic liquid compositions with polymeric rheology modifiers | FUS, MMAB, VCL | CHRNB4 4824/4885CHRNA3 4461/4885ALDH1A1 3389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.