Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 18/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19296814 | 0.87 | KRAS (0.47) | KITAKT1 | |
| SCHEMBL20340558 | 0.87 | KIT (0.52) | KIT | |
| SCHEMBL20340564 | 0.87 | KIT (0.48) | KIT | |
| SCHEMBL20340565 | 0.87 | KIT (0.48) | KIT | |
| SCHEMBL20340559 | 0.87 | KIT (0.51) | KIT | |
| SCHEMBL20340566 | 0.86 | KIT (0.49) | KIT | |
| SCHEMBL20340574 | 0.80 | ALDH1A1 (0.45) | KIT | |
| SCHEMBL20340560 | 0.80 | CYP1A2 (0.42) | KIT | |
| SCHEMBL20340567 | 0.79 | KIT (0.44) | KITAKT1 | |
| SCHEMBL16637222 | 0.79 | AKT1 (0.42) | KITAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011600-B2 | Methods and compositions for inhibition of Ras | ARAXES PHARMA LLC (US) | 2018-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011600-B2 | Methods and compositions for inhibition of Ras | KRAS, NRAS, HRAS | KIT 1512/4885AKT1 415/4885AKT3 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.