Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19381177 | 0.80 | NOTUM (0.45) | NOTUMMAPTTP53HTTKCNH2 | |
| SCHEMBL20342502 | 0.79 | TP53 (0.56) | NOTUMTP53LMNATSHRKMT2A | |
| SCHEMBL18216595 | 0.78 | MAPT (0.58) | NOTUMMAPTHTTGAAKDM4E | |
| SCHEMBL16122139 | 0.77 | NOTUM (0.41) | NOTUMMAPTTP53HTTGAA | |
| SCHEMBL15018021 | 0.75 | KMT2A (0.45) | NOTUMMAPTTP53GAAKCNH2 | |
| SCHEMBL17858623 | 0.74 | NOTUM (0.67) | NOTUMMAPTHTTALDH1A1LMNA | |
| SCHEMBL18216598 | 0.74 | NOTUM (0.45) | NOTUMMAPTTP53HTTGAA | |
| SCHEMBL18216589 | 0.73 | GPR119 (0.43) | NOTUMMAPTHTTGAAKDM4E | |
| SCHEMBL19381035 | 0.73 | MAPT (0.47) | NOTUMMAPTTP53HTTGAA | |
| SCHEMBL19381199 | 0.72 | GPR119 (0.43) | NOTUMALDH1A1F2KCNJ1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968288-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2018-07-04 | — | — | EP | disclosed |