Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 6/20 | 0.46 |
| ▸ | SYK | P43405 | 5/20 | 0.41 |
| ▸ | PAK4 | O96013 | 4/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | STK16 | O75716 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344031 | 0.78 | BTK (0.47) | JAK3BTK | |
| SCHEMBL20344055 | 0.77 | PAK4 (0.63) | MERTKPAK4JAK2PTK2JAK3 | |
| SCHEMBL1017607 | 0.77 | SYK (0.58) | SYKPAK4ULK1ADORA3 | |
| SCHEMBL20343964 | 0.76 | MERTK (0.40) | MERTKSYKTOP2AADORA3 | |
| SCHEMBL20344029 | 0.72 | BTK (0.45) | SYKJAK3BTK | |
| SCHEMBL20344027 | 0.70 | IRAK4 (0.39) | MERTKSYKPAK4TTKULK1 | |
| SCHEMBL13666490 | 0.69 | BTK (0.46) | JAK3BTK | |
| SCHEMBL1017293 | 0.68 | EHMT2 (0.41) | PAK4ADORA3 | |
| SCHEMBL12082657 | 0.66 | NPC1 (0.41) | TTK | |
| SCHEMBL24312397 | 0.66 | KMT2A (0.43) | ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-B1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARM INC (US) | 2018-07-04 | — | — | EP | disclosed |