Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | CD63 | P08962 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16848693 | 0.88 | CD63 (0.43) | SYKCD63MEN1KMT2AGAA | |
| SCHEMBL24904153 | 0.85 | BRAF (0.42) | SYKCD63GAAMAPTSMN1; SMN2 | |
| SCHEMBL14320302 | 0.83 | MAPT (0.55) | SYKCD63MEN1KMT2AGAA | |
| SCHEMBL15540550 | 0.81 | NR4A1 (0.46) | GAAMAPTSMN1; SMN2TBK1ALDH1A1 | |
| SCHEMBL16851815 | 0.80 | CD63 (0.38) | SYKCD63MEN1KMT2AGAA | |
| SCHEMBL30019224 | 0.80 | MAPT (0.52) | MEN1KMT2AGAAMAPTESRRG | |
| SCHEMBL17630840 | 0.78 | MAP3K12 (0.41) | GAAMAPTSMN1; SMN2TBK1JAK2 | |
| SCHEMBL27038804 | 0.76 | EML4 (0.42) | SYKMAPTTLR9TLR7HRH3 | |
| SCHEMBL17630392 | 0.75 | MAPT (0.62) | MEN1KMT2AGAAMAPTSMN1; SMN2 | |
| SCHEMBL30376114 | 0.75 | SMN1; SMN2 (0.51) | MEN1KMT2AGAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342773-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |