SCHEMBL20348319

SCHEMBL20348319

C[C@H](N)C(=O)O[C@@H](C)[C@H](c1ccc(F)cc1)C1CC1

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ SLC6A3 Q01959 3/20 0.39
▸ DPP4 P27487 2/20 0.38
▸ DPP9 Q86TI2 2/20 0.38
▸ DPP7 Q9UHL4 2/20 0.38
▸ KCNH2 Q12809 1/20 0.38
▸ DPP8 Q6V1X1 1/20 0.38
▸ SLC6A2 P23975 2/20 0.35
▸ SLC6A4 P31645 2/20 0.35
▸ MAPT P10636 1/20 0.35
▸ GRM7 Q14831 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20348315 0.87 CHRNA1 (0.36) SLC6A3DPP4DPP7DPP8SLC6A2
SCHEMBL20348312 0.81 TSHR (0.41) SLC6A3KCNH2SLC6A2MAPT
SCHEMBL20348321 0.81 TSHR (0.41) SLC6A3KCNH2SLC6A2MAPT
SCHEMBL22400670 0.79 HTT (0.40) MAPT
SCHEMBL21338895 0.79 DPP4 (0.39) DPP4DPP9DPP7KCNH2DPP8
SCHEMBL22400672 0.79 HTT (0.40) MAPT
SCHEMBL21339027 0.79 DPP4 (0.39) DPP4DPP9DPP7KCNH2DPP8
SCHEMBL22041429 0.79 DPP4 (0.39) DPP4DPP9DPP7KCNH2DPP8
SCHEMBL21339034 0.79 DPP4 (0.39) DPP4DPP9DPP7KCNH2DPP8
SCHEMBL21338900 0.79 DPP4 (0.39) DPP4DPP9DPP7KCNH2DPP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3565410-B1 PICOLINAMIDES AS FUNGICIDES CORTEVA AGRISCIENCE LLC (US) 2023-02-15 — — EP disclosed
US-10246417-B2 Picolinamides as fungicides DOW AGROSCIENCES LLC (US) 2019-04-02 — — US disclosed
WO-2018129237-A1 PICOLINAMIDES AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2018-07-12 — — WO disclosed
WO-2018129238-A1 PICOLINAMIDES AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2018-07-12 — — WO disclosed
US-20180186742-A1 PICOLINAMIDES AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2018-07-05 — — US disclosed
US-20180186742-A1 PICOLINAMIDES AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2018-07-05 — — US disclosed
US-20180186743-A1 PICOLINAMIDES AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2018-07-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180186743-A1 PICOLINAMIDES AS FUNGICIDES CYP1A2, CYP4F12, FKBP2 SLC6A3 2170/4885DPP4 557/4885DPP9 322/4885
US-10246417-B2 Picolinamides as fungicides CYP1A2, CYP4F12, FKBP2 SLC6A3 2170/4885DPP4 557/4885DPP9 322/4885
US-20180186742-A1 PICOLINAMIDES AS FUNGICIDES CYP1A2, CYP4F12, FKBP2 SLC6A3 2170/4885DPP4 557/4885DPP9 322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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