Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 12/20 | 0.49 |
| ▸ | GLA | P06280 | 12/20 | 0.49 |
| ▸ | HPGD | P15428 | 9/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20340182 | 0.87 | KDM4E (0.64) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL20350815 | 0.82 | KDM4E (0.68) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL20340016 | 0.81 | KDM4E (0.64) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL20340052 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL20339496 | 0.77 | KDM4E (0.70) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL20340123 | 0.75 | KDM4E (0.67) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL20339508 | 0.74 | KDM4E (1.00) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL20339938 | 0.73 | KDM4E (0.74) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL26847329 | 0.73 | KDM4E (0.74) | KDM4EALDH1A1MAPTGAAGLA | |
| SCHEMBL24088111 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1MAPTGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018125983-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |