Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 13/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20350995 | 0.88 | ACMSD (0.47) | ACMSDADORA2AADORA1ADORA2BCYP2C19 | |
| SCHEMBL20339975 | 0.86 | ACMSD (0.64) | ACMSDADORA2AADORA1ADORA2BCYP2C19 | |
| SCHEMBL20351077 | 0.85 | ACMSD (0.46) | ACMSDADORA1KMT2AALDH1A1HPGD | |
| SCHEMBL20351090 | 0.85 | ACMSD (0.49) | ACMSDADORA2AADORA1ADORA2BCYP2C19 | |
| SCHEMBL26847199 | 0.81 | ACMSD (0.48) | ACMSDADORA2AADORA1ADORA2BCYP2C19 | |
| SCHEMBL23850235 | 0.81 | ACMSD (0.64) | ACMSDADORA2AADORA1ADORA2BCYP2C19 | |
| SCHEMBL24087956 | 0.76 | KDM4E (0.46) | ACMSDADORA2AADORA1CYP2C19KDM4E | |
| SCHEMBL26847345 | 0.74 | KDM4E (0.46) | ACMSDADORA2AADORA1KDM4EPIM1 | |
| SCHEMBL24088040 | 0.74 | ACMSD (0.44) | ACMSDADORA2AADORA1ADORA2BCYP2C19 | |
| SCHEMBL24088014 | 0.74 | ACMSD (0.68) | ACMSDADORA2AADORA1ADORA2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018125983-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |