ACMSD — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL330602	1.00	10/20
SCHEMBL411333	0.65	10/20
SCHEMBL330405	0.72	8/20
SCHEMBL330966	0.59	8/20
Diflunisal (SCHEMBL4337)	1.00	7/20
SCHEMBL412439	1.00	7/20
SCHEMBL330660	0.66	7/20
SCHEMBL444743	0.62	7/20
SCHEMBL313199	0.62	7/20
SCHEMBL412559	0.55	7/20
Diflunisal (SCHEMBL625748)	0.89	6/20
Salsalate (SCHEMBL360114)	0.70	6/20
SCHEMBL692615	0.50	6/20
SCHEMBL569383	0.68	5/20
SCHEMBL6460	0.61	5/20
SCHEMBL33365	0.56	5/20
SCHEMBL742865	0.54	5/20
SCHEMBL277684	0.54	5/20
Biphenyl (SCHEMBL509719)	0.51	5/20
SCHEMBL757811	0.42	5/20

Clinical trials — most relevant to ACMSD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Citrate- Versus Acetate-Based Dialysate in Bicarbonate Haemodialysis: Consequences on Haemodynamics, Coagulation, Acid-Base Status and Electrolytes	PHASE4	COMPLETED
Efficiency and Biocompatibility in Hemodiafiltration Procedure	PHASE4	COMPLETED
Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 75 Years of Age in India	PHASE3	COMPLETED
Octohydroaminoacridine Succinate Tablet for Mild-to-Moderate Alzheimer's Disease	PHASE3	UNKNOWN
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Comparative Evaluation of Three Different Pulpotomy Agents in Primary Molars	PHASE2	ACTIVE_NOT_RECRUITING
Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate	PHASE2	WITHDRAWN
Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress in Patients With Poly Cystic Ovary Syndrome	PHASE2	COMPLETED
Pilot Trial of Acamprosate for the Treatment of Cocaine Dependence	PHASE2	COMPLETED
Treatment of Temporo-Myofascial Disorder of Muscular Origin Using Botulinum Toxin: A Prospective Study	PHASE2	UNKNOWN
Preventive Effect of Acetyl-L-carnitine on Oxaliplatin-induced Peripheral Neuropathy	PHASE2	UNKNOWN
A Study of ACI-24 in Adults With Down Syndrome	PHASE2	WITHDRAWN
A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure	PHASE2	NOT_YET_RECRUITING
Study of Octohydroaminoacridine Succinate Tablets in Patients With Alzheimer's Disease	PHASE2	UNKNOWN
Booster Dose Study to Assess the Safety and Immunogenicity of ACM-001 Administered Intramuscularly or Intranasally.	PHASE1	COMPLETED
Safety and Tolerability of ACU-4429	PHASE1	COMPLETED
NCCL Direct Composite Restoration Performance With Self-Etch and Multimode Adhesives	nan	COMPLETED
Evaluation of Hydroxymethylbutyrate Supplementation in Lung Transplant Candidates Receiving Pulmonary Rehabilitation	nan	COMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
European Survey: Risk of Cyanide Poisoning in Smoke Inhalation	nan	COMPLETED
Efficacy of BST-CarGel in Treating Chondral Lesions of the Hip	nan	WITHDRAWN
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
The Ketogenic Diet in the Treatment of Behavioral Variant Frontotemporal Dementia	nan	NOT_YET_RECRUITING
Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose	nan	ACTIVE_NOT_RECRUITING
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Treatment Response in Schizophrenia: Bridging Imaging and Postmortem Studies	nan	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial	nan	COMPLETED
Microbiome Composition and Biomarker Discovery in Refractory Pediatric Epilepsy	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a ACMSD binder may also engage these)

Protein	Name	Similarity
Q0II68	—	0.999	Q0II68 →
Q8R519	—	0.978	Q8R519 →
Q8R5M5	—	0.973	Q8R5M5 →
Q6P8M1	—	0.954	Q6P8M1 →
Q148G4	—	0.946	Q148G4 →
Q6P1N9	—	0.943	Q6P1N9 →
Q6B855	—	0.939	Q6B855 →
TKT	Transketolase	0.938	landscape →
Q07346	—	0.937	Q07346 →
P40142	—	0.936	P40142 →
P50137	—	0.935	P50137 →
Q9ZPS3	—	0.935	Q9ZPS3 →
CTH	Cystathionine gamma-lyase	0.934	landscape →
Q5R4C1	—	0.933	Q5R4C1 →
Q42521	—	0.933	Q42521 →
P36959	—	0.932	P36959 →
Q60HG7	—	0.931	Q60HG7 →
P61922	—	0.931	P61922 →
Q60HC7	—	0.930	Q60HC7 →
Q42472	—	0.930	Q42472 →
OAT	Ornithine aminotransferase, mitochondrial	0.930	landscape →
Q5R1W6	—	0.930	Q5R1W6 →
P04182	—	0.929	P04182 →
Q9DCZ1	—	0.928	Q9DCZ1 →
P29758	—	0.928	P29758 →
Q8FB30	—	0.928	Q8FB30 →
Q9Z244	—	0.928	Q9Z244 →
Q3ZCF5	—	0.927	Q3ZCF5 →
A3QK15	—	0.927	A3QK15 →
Q95LI9	—	0.925	Q95LI9 →