SCHEMBL20351504 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	ADK	P55263	5/20	0.53

▸	RET	P07949	4/20	0.44

▸	SRC	P12931	5/20	0.42

▸	LCK	P06239	4/20	0.42

▸	TEK	Q02763	2/20	0.42

▸	HCK	P08631	1/20	0.42

▸	RIPK2	O43353	2/20	0.39

▸	EIF2AK3	Q9NZJ5	3/20	0.38

▸	ABL1	P00519	3/20	0.36

▸	FYN	P06241	2/20	0.36

▸	FLT1	P17948	2/20	0.36

▸	LTK	P29376	2/20	0.36

▸	KDR	P35968	2/20	0.36

▸	MAP2K2	P36507	2/20	0.36

▸	FLT3	P36888	2/20	0.36

▸	CDK8	P49336	2/20	0.36

▸	MAP2K1	Q02750	2/20	0.36

▸	ACVR1	Q04771	2/20	0.36

▸	TNK2	Q07912	2/20	0.36

▸	NTRK3	Q16288	2/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20351619	0.92	ADK (0.51)	ADKRETSRCLCKTEK
SCHEMBL20351622	0.90	ADK (0.56)	ADKRETSRCLCKRIPK2
SCHEMBL19264034	0.87	ADK (0.53)	ADKRETSRCLCKRIPK2
SCHEMBL20351756	0.87	ADK (0.53)	ADKRETSRCLCKTEK
SCHEMBL20351760	0.86	ADK (0.55)	ADKRETSRCLCKTEK
SCHEMBL29780875	0.83	ADK (0.52)	ADKRETSRCLCKTEK
SCHEMBL16769982	0.83	ADK (0.52)	ADKRETSRCLCKTEK
SCHEMBL1787110	0.83	ADK (0.52)	ADKRETSRCLCKTEK
SCHEMBL23732927	0.80	ADK (0.55)	ADKRETSRCLCKRIPK2
SCHEMBL20351806	0.79	ADK (0.46)	ADKRETSRCLCKTEK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018121228-A1	COMPOUND HAVING AXL INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF	中国科学院上海药物研究所	2018-07-05	—	—	WO	disclosed