Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 13/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20351721 | 0.87 | SRC (0.41) | EIF2AK3SRCRIPK1LCKKDR | |
| SCHEMBL20351783 | 0.85 | RIPK2 (0.61) | EIF2AK3SRCFLT3RIPK2MET | |
| SCHEMBL20351597 | 0.85 | EIF2AK3 (0.50) | EIF2AK3SRCFLT3RIPK2LCK | |
| SCHEMBL20351744 | 0.83 | SRC (0.57) | EIF2AK3SRCLCKKDRTEK | |
| SCHEMBL18044717 | 0.81 | KDR (0.59) | SRCFLT3RIPK2LCKKDR | |
| SCHEMBL23966767 | 0.81 | RIPK2 (0.69) | SRCFLT3RIPK2LCKKDR | |
| SCHEMBL30180693 | 0.81 | RIPK2 (0.69) | SRCFLT3RIPK2LCKKDR | |
| SCHEMBL12608277 | 0.81 | EIF2AK3 (0.45) | EIF2AK3SRCFLT3RIPK1LCK | |
| SCHEMBL13020096 | 0.79 | SRC (0.69) | EIF2AK3SRCFLT3RIPK2LCK | |
| SCHEMBL23917434 | 0.79 | SRC (0.61) | SRCFLT3RIPK2LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036014-B | Compound with AXL inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2021-09-07 | — | — | CN | disclosed |
| WO-2018121228-A1 | COMPOUND HAVING AXL INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2018-07-05 | — | — | WO | disclosed |