Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 10/20 | 0.50 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | SRC | P12931 | 4/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | KIF5B | P33176 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | CCDC6 | Q16204 | 3/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20351614 | 0.90 | SRC (0.42) | EIF2AK3KDRSRCLCKTEK | |
| SCHEMBL20351544 | 0.85 | EIF2AK3 (0.49) | EIF2AK3KDRSRCLCKTEK | |
| SCHEMBL20351783 | 0.84 | RIPK2 (0.61) | EIF2AK3SRCFLT3RIPK2MET | |
| SCHEMBL13020096 | 0.83 | SRC (0.69) | EIF2AK3KDRSRCLCKTEK | |
| SCHEMBL24458348 | 0.83 | RET (0.56) | EIF2AK3KDRSRCLCKTEK | |
| SCHEMBL20351744 | 0.82 | SRC (0.57) | EIF2AK3KDRSRCLCKTEK | |
| SCHEMBL18044717 | 0.80 | KDR (0.59) | KDRSRCLCKTEKABL1 | |
| SCHEMBL29998988 | 0.80 | RIPK2 (0.69) | KDRSRCLCKABL1EGFR | |
| SCHEMBL23966798 | 0.80 | RIPK2 (0.69) | KDRSRCLCKABL1EGFR | |
| SCHEMBL2075497 | 0.78 | SRC (0.68) | KDRSRCLCKTEKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036014-B | Compound with AXL inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2021-09-07 | — | — | CN | disclosed |
| WO-2018121228-A1 | COMPOUND HAVING AXL INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2018-07-05 | — | — | WO | disclosed |