Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 18/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | SIK1 | P57059 | 1/20 | 0.43 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | DSTYK | Q6XUX3 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20351785 | 0.88 | EIF2AK3 (0.44) | EIF2AK3KDR | |
| SCHEMBL20351577 | 0.86 | EIF2AK3 (0.50) | EIF2AK3SRCRIPK2PDGFRBKIT | |
| SCHEMBL20351494 | 0.82 | EIF2AK3 (0.52) | EIF2AK3SRCRIPK2PDGFRBKIT | |
| SCHEMBL20351783 | 0.81 | RIPK2 (0.61) | EIF2AK3SRCRIPK2FLT3 | |
| SCHEMBL23966766 | 0.79 | RIPK2 (0.65) | SRCRIPK2PDGFRBKITFLT3 | |
| SCHEMBL20351797 | 0.79 | EIF2AK3 (0.48) | EIF2AK3SRCRIPK2FLT3ABL1 | |
| SCHEMBL6430725 | 0.77 | EIF2AK3 (0.46) | EIF2AK3PI4KB | |
| SCHEMBL30544150 | 0.77 | EIF2AK3 (0.62) | EIF2AK3 | |
| SCHEMBL19743322 | 0.77 | EIF2AK3 (0.62) | EIF2AK3 | |
| SCHEMBL23917445 | 0.76 | PIK3CD (0.57) | EIF2AK3SRCPIK3CDABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036014-B | Compound with AXL inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2021-09-07 | — | — | CN | disclosed |
| WO-2018121228-A1 | COMPOUND HAVING AXL INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2018-07-05 | — | — | WO | disclosed |