Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 7/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 9/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18044685 | 0.95 | ADK (0.51) | ADKSLC29A1ABL1MAP4K4PAK4 | |
| SCHEMBL6866845 | 0.90 | ADK (0.47) | ADKSLC29A1ABL1MAP4K4PAK4 | |
| SCHEMBL16236759 | 0.90 | ADK (0.47) | ADKSLC29A1ABL1MAP4K4PAK4 | |
| SCHEMBL16236581 | 0.88 | ADK (0.49) | ADKSLC29A1HTR6 | |
| SCHEMBL1939761 | 0.87 | ADK (0.52) | ADKSLC29A1ABL1MAP4K4PAK4 | |
| SCHEMBL401328 | 0.87 | ADK (0.52) | ADKSLC29A1ABL1MAP4K4PAK4 | |
| SCHEMBL20351806 | 0.86 | ADK (0.46) | ADKABL1MAP4K4PAK4LCK | |
| SCHEMBL16236685 | 0.86 | ADK (0.51) | ADKSLC29A1ABL1MAP4K4PAK4 | |
| SCHEMBL22086530 | 0.86 | ADK (0.51) | ADKSLC29A1ABL1MAP4K4PAK4 | |
| SCHEMBL30373169 | 0.86 | ADK (0.51) | ADKSLC29A1ABL1MAP4K4PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036014-B | Compound with AXL inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2021-09-07 | — | — | CN | disclosed |
| WO-2018121228-A1 | COMPOUND HAVING AXL INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2018-07-05 | — | — | WO | disclosed |