Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2035034 | 0.87 | PDE10A (0.57) | PDE10AKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL2041258 | 0.87 | PDE10A (0.54) | PDE10AKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL2038023 | 0.85 | PDE10A (0.53) | PDE10AKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL2041707 | 0.85 | PDE10A (0.57) | PDE10A | |
| SCHEMBL2051643 | 0.85 | PDE10A (0.58) | PDE10A | |
| SCHEMBL2035589 | 0.84 | PDE10A (0.51) | PDE10A | |
| SCHEMBL2039532 | 0.82 | PDE10A (0.49) | PDE10AKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL2053912 | 0.81 | PDE10A (0.57) | PDE10AKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL2042164 | 0.79 | PDE10A (0.51) | PDE10A | |
| SCHEMBL2038712 | 0.77 | PDE10A (0.47) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072695-A1 | PHENYLIMIDAZOLE DERIVATIVES COMPRISING AN ETHYNYLENE LINKER AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | claimed |