Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038930 | 0.84 | PDE10A (0.45) | PDE10ASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL2041258 | 0.83 | PDE10A (0.54) | PDE10ASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL2035449 | 0.82 | PDE10A (0.58) | PDE10ASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL2035034 | 0.81 | PDE10A (0.57) | PDE10ASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL2041707 | 0.79 | PDE10A (0.57) | PDE10A | |
| SCHEMBL2038023 | 0.79 | PDE10A (0.53) | PDE10ASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL2039086 | 0.79 | PDE10A (0.36) | PDE10A | |
| SCHEMBL2035589 | 0.78 | PDE10A (0.51) | PDE10AMAP4K4CLK4 | |
| SCHEMBL2042164 | 0.73 | PDE10A (0.51) | PDE10A | |
| SCHEMBL2051643 | 0.72 | PDE10A (0.58) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072695-A1 | PHENYLIMIDAZOLE DERIVATIVES COMPRISING AN ETHYNYLENE LINKER AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | claimed |