Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.63 |
| ▸ | FLT1 | P17948 | 8/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.63 |
| ▸ | FLT4 | P35916 | 3/20 | 0.63 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 6/20 | 0.61 |
| ▸ | RET | P07949 | 6/20 | 0.61 |
| ▸ | KIF5B | P33176 | 6/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20355392 | 0.90 | KDR (0.64) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL20354974 | 0.90 | KDR (0.65) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL21557410 | 0.88 | KDR (0.62) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL21557447 | 0.87 | KDR (0.83) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL24245152 | 0.85 | KDR (0.59) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL21541684 | 0.84 | EGFR (0.66) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL30792543 | 0.84 | EGFR (0.66) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL21557441 | 0.84 | KDR (0.71) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL20355323 | 0.83 | KDR (0.86) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL20355393 | 0.83 | KDR (0.64) | KDRFLT1FGFR1FLT4EPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018121758-A1 | QUINAZOLINE COMPOUND FOR EGFR INHIBITION | 南京明德新药研发股份有限公司 | 2018-07-05 | — | — | WO | disclosed |