Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.64 |
| ▸ | RET | P07949 | 7/20 | 0.64 |
| ▸ | KIF5B | P33176 | 6/20 | 0.64 |
| ▸ | EGFR | P00533 | 7/20 | 0.64 |
| ▸ | FLT1 | P17948 | 5/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21557410 | 0.90 | KDR (0.62) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL21557366 | 0.88 | KDR (0.83) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL20355392 | 0.88 | KDR (0.64) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL20354974 | 0.85 | KDR (0.65) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL20355323 | 0.85 | KDR (0.86) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL21557447 | 0.84 | KDR (0.83) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL21541684 | 0.83 | EGFR (0.66) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL30792543 | 0.83 | EGFR (0.66) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL21557441 | 0.83 | KDR (0.71) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL20354973 | 0.83 | KDR (0.63) | KDRRETKIF5BEGFRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567030-B1 | QUINAZOLINE COMPOUND FOR EGFR INHIBITION | MEDSHINE DISCOVERY INC (CN) | 2022-02-09 | — | — | EP | disclosed |
| WO-2018121758-A1 | QUINAZOLINE COMPOUND FOR EGFR INHIBITION | 南京明德新药研发股份有限公司 | 2018-07-05 | — | — | WO | disclosed |