Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | NPR1 | P16066 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20355409 | 0.82 | MCHR1 (0.36) | MCHR1HPGDIRAK4DDB1CRBN | |
| SCHEMBL23946259 | 0.79 | DDB1 (0.34) | MCHR1HPGDIRAK4DDB1CRBN | |
| SCHEMBL20355408 | 0.78 | KDM4E (0.38) | MCHR1HPGDIRAK4DDB1CRBN | |
| SCHEMBL20355407 | 0.73 | DPP4 (0.31) | DPP4DPP9 | |
| SCHEMBL24869066 | 0.72 | RECQL (0.39) | HPGDPTGS1PTGS2ROCK2HSP90AA1 | |
| SCHEMBL15173416 | 0.70 | ALDH1A1 (0.43) | HPGDHTTROCK2NPC1POLB | |
| SCHEMBL14993992 | 0.66 | HPGD (0.36) | HPGDIRAK4ROCK2NPC1POLB | |
| SCHEMBL10175327 | 0.66 | KDM4E (0.46) | HPGDROCK2KDM4E | |
| SCHEMBL29526795 | 0.66 | KDM4E (0.46) | HPGDROCK2KDM4E | |
| SCHEMBL15636252 | 0.65 | HPGD (0.49) | HPGDROCK2NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018125800-A2 | METALLOENZYME INHIBITOR COMPOUNDS | VIAMET PHARMACEUTICALS (BERMUDA), LTD. (BM) | 2018-07-05 | — | — | WO | disclosed |