Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.42 |
| ▸ | JAK3 | P52333 | 9/20 | 0.42 |
| ▸ | JAK1 | P23458 | 5/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996069 | 0.91 | EIF2AK4 (0.45) | JAK2JAK3JAK1MKNK1MKNK2 | |
| SCHEMBL1997090 | 0.89 | JAK2 (0.40) | JAK2JAK3JAK1MKNK1MKNK2 | |
| SCHEMBL1995485 | 0.87 | IRAK4 (0.42) | JAK2JAK3JAK1MKNK1MKNK2 | |
| SCHEMBL1994136 | 0.79 | JAK2 (0.42) | JAK2JAK3JAK1MKNK1MKNK2 | |
| SCHEMBL12613453 | 0.75 | HRH4 (0.40) | EIF2AK4FLT3 | |
| SCHEMBL1996606 | 0.75 | JAK2 (0.40) | JAK2JAK3JAK1EIF2AK4FLT3 | |
| SCHEMBL12615023 | 0.75 | USP1 (0.43) | JAK2JAK3JAK1CYP3A4FLT3 | |
| SCHEMBL2033850 | 0.73 | EIF2AK4 (0.54) | EIF2AK4 | |
| SCHEMBL1997645 | 0.73 | EIF2AK4 (0.45) | JAK2JAK3JAK1EIF2AK4FLT3 | |
| SCHEMBL1999723 | 0.72 | PRMT5 (0.41) | JAK2JAK3JAK1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |