Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21526112 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2HTTCCR2EPHX1GAA | |
| SCHEMBL21526116 | 0.71 | HTT (0.44) | SMN1; SMN2HTTMAPTTDP1LMNA | |
| SCHEMBL21526019 | 0.71 | HTT (0.46) | SMN1; SMN2HTTMAPTTDP1LMNA | |
| SCHEMBL21526098 | 0.69 | SMN1; SMN2 (0.44) | SMN1; SMN2HTTNPC1CCR2EPHX1 | |
| SCHEMBL28323231 | 0.68 | HTT (0.42) | SMN1; SMN2HTTMAPTTDP1LMNA | |
| SCHEMBL21526039 | 0.68 | HTT (0.46) | SMN1; SMN2HTTLMNAALDH1A1HPGD | |
| SCHEMBL21526061 | 0.68 | KDM4E (0.42) | SMN1; SMN2HTTLMNANPC1L3MBTL1 | |
| SCHEMBL20356574 | 0.67 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTLMNANPC1CCR2 | |
| SCHEMBL21526051 | 0.67 | SMN1; SMN2 (0.39) | SMN1; SMN2HTTL3MBTL1CCR2EPHX1 | |
| SCHEMBL21548938 | 0.67 | SMN1; SMN2 (0.39) | SMN1; SMN2HTTMAPTTDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018124000-A1 | PYRIMIDINE DERIVATIVE | 第一三共株式会社 | 2018-07-05 | — | — | WO | disclosed |