⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15872754 | 1.00 | — | — | |
| SCHEMBL20357914 | 1.00 | — | — | |
| SCHEMBL15883707 | 0.89 | SPHK1 (0.38) | — | |
| SCHEMBL15872867 | 0.85 | — | — | |
| SCHEMBL21768526 | 0.85 | — | — | |
| SCHEMBL15873310 | 0.85 | — | — | |
| SCHEMBL22115984 | 0.85 | — | — | |
| SCHEMBL16504650 | 0.83 | — | — | |
| SCHEMBL20368617 | 0.80 | — | — | |
| SCHEMBL15894755 | 0.77 | SPHK1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10265307-B2 | Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors | INCYTE CORPORATION (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180193323-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2018-07-12 | — | — | US | disclosed |