Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23126366 | 0.86 | TRPM8 (0.67) | TRPM8 | |
| SCHEMBL19915369 | 0.84 | TRPM8 (0.53) | TRPM8POLBATMALDH1A1SMN1; SMN2 | |
| SCHEMBL19915377 | 0.80 | TRPM8 (0.60) | TRPM8ALDH1A1SMN1; SMN2TP53MEN1 | |
| SCHEMBL17233487 | 0.80 | TRPM8 (0.61) | TRPM8POLBATMALDH1A1SMN1; SMN2 | |
| SCHEMBL17233499 | 0.79 | TRPM8 (0.61) | TRPM8POLBATMALDH1A1SMN1; SMN2 | |
| SCHEMBL17233494 | 0.78 | TRPM8 (0.60) | TRPM8POLBATMALDH1A1SMN1; SMN2 | |
| SCHEMBL20662386 | 0.77 | TRPM8 (0.51) | TRPM8POLBATMALDH1A1TP53 | |
| SCHEMBL17233497 | 0.75 | TRPM8 (0.56) | TRPM8POLBATMALDH1A1SMN1; SMN2 | |
| SCHEMBL20662363 | 0.74 | TRPM8 (0.55) | TRPM8POLBATMALDH1A1SMN1; SMN2 | |
| SCHEMBL2729724 | 0.73 | TRPM8 (0.68) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10016418-B2 | Compounds useful as modulators of TRPM8 | Seaomyx, Inc. (US) | 2018-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10016418-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPM6 | TRPM8 1/4885POLB 4439/4885ATM 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.