Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 12/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16939708 | 1.00 | MME (0.36) | MMEACEFFAR4FASNCTSD | |
| SCHEMBL19331579 | 0.85 | MME (0.38) | MMEACEFFAR4FASN | |
| SCHEMBL20364010 | 0.82 | PAK1 (0.35) | MMEACEFFAR4FASN | |
| SCHEMBL19376969 | 0.82 | PAK1 (0.35) | MMEACEFFAR4FASN | |
| SCHEMBL16942417 | 0.82 | PAK1 (0.35) | MMEACEFFAR4FASN | |
| SCHEMBL16939705 | 0.81 | FASN (0.35) | MMEACEFFAR4FASNCTSD | |
| SCHEMBL16939700 | 0.80 | MME (0.37) | MMEACE | |
| SCHEMBL16939707 | 0.77 | MME (0.35) | MMEACEFFAR4 | |
| SCHEMBL16939238 | 0.76 | MME (0.36) | MMEACEFFAR4FASN | |
| SCHEMBL19407282 | 0.76 | FFAR4 (0.39) | MMEACEFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180193338-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180193338-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | MME 1/4885ACE 3/4885FFAR4 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.