Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 16/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.80 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376433 | 0.89 | HDAC2 (1.00) | HDAC2HDAC1GSK3B | |
| SCHEMBL13739161 | 0.74 | HDAC2 (0.70) | HDAC2HDAC1 | |
| SCHEMBL18079544 | 0.74 | HDAC2 (0.55) | HDAC2HDAC1 | |
| SCHEMBL18376432 | 0.73 | HDAC2 (0.71) | HDAC2HDAC1 | |
| SCHEMBL18079545 | 0.73 | HDAC2 (0.66) | HDAC2HDAC1 | |
| SCHEMBL13833449 | 0.73 | HDAC2 (0.78) | HDAC2HDAC1 | |
| SCHEMBL21480711 | 0.70 | HDAC2 (0.49) | HDAC2HDAC1 | |
| SCHEMBL19860009 | 0.69 | HDAC2 (0.58) | HDAC2HDAC1 | |
| SCHEMBL13833393 | 0.69 | HDAC2 (0.65) | HDAC2HDAC1 | |
| SCHEMBL20343601 | 0.65 | JAK1 (0.52) | HDAC2HDAC1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194769-A1 | HETERO-HALO INHIBITORS OF HISTONE DEACETYLASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194769-A1 | HETERO-HALO INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC6 | HDAC2 1/4885HDAC1 2/4885GSK3B 755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.